研究

具有类似香烟尼古丁递送功能的电子烟可能有助于吸烟者戒烟

A College of 医学-led research study found electronic cigarettes with cigarette-like nicotine delivery may help some people stop smoking cigarettes. 来源:Getty Images | 和repopov. 保留所有权利.

宾夕法尼亚州. — Electronic cigarettes with cigarette-like nicotine delivery may help some people stop smoking cigarettes, 根据一项新的研究 宾夕法尼亚州立医学院弗吉尼亚联邦大学 研究人员. 改用电子烟, 研究人员说,烟草使用者可能会减少与某些致癌物的接触, 或者致癌物质.

了六个月, the research team followed 520 smokers who were looking to reduce their cigarette consumption by at least 50% but had no plans to quit. 的y observed whether the use of various electronic nicotine delivery systems (or ENDS) — used by around 10 million U.S. 成年人-导致香烟消费减少. 参与者随机接受含0 mg/mL的ENDS(安慰剂), 8毫克/毫升或36毫克/毫升尼古丁, 或者不含尼古丁的香烟替代品, 电子或气溶胶.

Throughout the study, 研究人员 encouraged participants to reduce their cigarette consumption. 六个月后, 明显更多的参与者接受了36 mg/mL的尼古丁末端物, 哪一种与香烟有相似的尼古丁传递, 报告显示,与其他研究小组相比,他们仍然戒烟.

“全面, 戒烟率很低,因为参加试验的参与者中没有人计划戒烟, 在这六个月里,他们也没有收到戒烟的建议,” 乔纳森福尔兹他是医学院公共卫生科学的主要作者和教授. “然而, 随着时间的推移, we noticed that the number of those receiving the high nicotine-delivery ENDS who abstained from cigarettes gradually increased. That trend was not observed in those receiving the placebo ENDS or the non-ENDS cigarette substitute.

"This is the first r和omized clinical trial of electronic cigarettes to find that a nicotine e-cig produced a significant increase in smoking cessation at six months follow-up, 与安慰剂电子烟和非ends香烟替代品相比,”福尔兹说.

之前的试验已经研究了ENDS对戒烟的影响, but the 研究人员 noted many of those studies used devices 和 liquids with unknown or unconfirmed nicotine delivery profiles.

“One of the strengths of our study was that the nicotine delivery of the specific ENDS device paired with the different liquids used in this study were confirmed before the trial,” 托马斯Eissenberg他是弗吉尼亚联邦大学的合著者和教授. “It is evident based on our findings that ENDS with ineffective or less potent nicotine delivery likely won’t help participants to quit cigarette smoking.”

的 研究人员 encouraged participants to reduce their cigarette consumption by 50% 和 then 75% for a six-month period. 他们测量了香烟消耗量和各种生物标志物, 比如呼出的一氧化碳水平, 在8次随访中. 的y determined the proportion of participants in each group who reported that they had smoked no cigarettes in the prior week. 在六个月的时候, significantly more participants in the 36 mg/mL nicotine group (about 11%) reported cigarette abstinence than in the 0 mg/mL (1%) 和 cigarette substitute (3%) groups. Approximately 5% of participants in the 8 mg/mL group reported cigarette abstinence at the six-month mark. 

“We were surprised to see that the 8 mg/mL group didn’t have a significantly higher quit rate than the placebo group,” 杰西卡Yingst, 宾州州立癌症研究所 researcher 和 assistant professor of public health sciences at 宾夕法尼亚州立医学院. “这些结果表明,如果ENDS没有香烟释放出那么多的尼古丁, 那么使用这些设备的吸烟者戒烟的可能性就更小了.”

根据研究人员的说法, 他们研究的主要结论是,当人们试图减少吸烟时,尝试ENDS, 很少有人能在短期内戒烟. 然而, smokers that continued to use an ENDS with cigarette-like nicotine delivery (the 36 mg/mL group), 更有可能在短期内戒烟,并完全转换到ENDS, 与使用安慰剂的人相比. Devices with nicotine delivery similar to a cigarette may be more effective in enabling ambivalent smokers to quit cigarettes. 的 结果 发表在《手机买球app官网》杂志上.

“除了在试验结束时有更高的戒烟率, the 36 mg/mL group also reported more days without smoking cigarettes throughout the trial than the other three groups,” 卡罗琳·科布作者之一、弗吉尼亚联邦大学副教授.

的 study team said that more research is needed to confirm 和 exp和 upon their findings, but they were encouraged that participants using ENDS products while still smoking cigarettes did not have a higher frequency of serious adverse events. 的y noted that the medical monitors did not attribute any serious adverse events observed during the study to the use of the ENDS devices.

“的 结果 of our study reflect many patterns of ENDS use that have been found in other studies 和 in society in general,”福尔兹说, 他是手机买球app下载癌症研究所的研究员. “Many people use ENDS 和 continue smoking cigarettes for a period of time before quitting smoking. 目的不是灵丹妙药, but our 结果 support the idea that ENDS with cigarette-like nicotine delivery may be critical to someone’s ability to abstain from cigarettes.”

苏珊Veldheer, 莎丽Hrabovsky, 索菲娅•艾伦, 习王, 克里斯Sciamanna, 艾琳·汉密, Breianna悍马, Courtney Lester 和 John Richie of 宾夕法尼亚州立医学院; Miao-Shan Yen, 菲比·布鲁斯南, Nadia Chowdhury, 雅各布·格雷厄姆, Le Kang 和 Shumei Sun of 弗吉尼亚联邦大学; Alexa Lopez of University of Wisconsin-Milwaukee; 和 Christopher Bullen of University of Auckl和 also contributed to this research. Foulds has done paid consulting for pharmaceutical companies involved in manufacturing smoking-cessation medications (e.g.辉瑞,葛兰素史克,约翰逊 & Johnson); 和 has acted as a deposed 和 compensated expert witness on behalf of plaintiffs suing cigarette manufacturers. 其他作者的披露可在 出版的手稿.

This research was supported by the National Institute on Drug Abuse of the National Institutes of Health (grants P50DA036105 和 U54DA036105) 和 the Center for Tobacco Products of the U.S. 食品和药物管理局. Data collection was supported by the National Center for Advancing Translational Sciences through grants (UL1TR002649 to 弗吉尼亚联邦大学 和 UL1TR002014 to Penn State through Penn State 临床与转化科学研究所). 的 content is solely the responsibility of the authors 和 does not necessarily represent the official views of the National Institutes of Health or the 食品和药物管理局.

最后更新于2021年12月15日

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